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50-78-2 - O-Acetylsalicylic acid, 99% - 2-Acetoxybenzoic acid - A12488 - Alfa Aesar

A12488 O-Acetylsalicylic acid, 99%

CAS Number
50-78-2
Synonyms
2-Acetoxybenzoic acid

Size Price ($) Quantity Availability
100g 17.64
500g 40.27
2500g 147.29
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O-Acetylsalicylic acid, 99%

MDL
MFCD00002430
EINECS
200-064-1

Chemical Properties

Formula
C9H8O4
Formula Weight
180.15
Melting point
133-140°
Flash Point
250°(482°F)
Density
1.400
Solubility
Soluble in 100% ethanol (80mg/ml), DMSO (41mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in Phosphate-buffered saline (PBS), pH 7.2 (2.7mg/ml).

Applications

O-Acetylsalicylic acid is the prototypical analgesic used in the treatment of mild to moderate pain. acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. Along with sodium salicylate (sc-3520), aspirin has been shown to block the long terminal repeat from the human immunodeficiency virus and the Ig κ enhancer from NFκB dependent transcription.

Notes

Store at room temperature. Ensure good ventilation.

Literature References

D W Gilroy et. Al. Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation. Eur. J. Pharmacol. 1998, 355 (2-3),211-217.

K Schrör. Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Seminars in Thrombosis and Hemostasis. 1997, 23 (4),349-356.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,851
Beilstein
779271
Harmonized Tariff Code
2918.22
TSCA
Yes
RTECS
VO0700000

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