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Superoxide scavenger with neuroprotective, anti-inflammatory and analgesic effects4-Hydroxy-TEMPO free radical is used as a catalyst and a chemical oxidant by virtue of being a stable radical. It is used for detoxifying reactive oxygen species in medicinal chemistry. It is involved in the catalysis of disproportionation of superoxide and facilitates hydrogen peroxide metabolism. It is used to prepare tris(2,2,6,6-tetramethyl-1-oxyl-4-piperidyloxy)trimellitate by reacting with benzene-1,2,4-tricarbonyl trichloride. Further, it is used as a free radical scavenger and exhibits neuroprotective, anti-inflammatory and analgesic effects. In addition to this, it has good inhibition effect to acrylic acid esters, methyl acrylate, acrylic acid, acrylonitrile, styrene and butadiene.
Reviews: Synthesis and reactions of stable nitroxyl radicals: Synthesis, 190, 401 (1971); Advances in the chemistry of nitroxide spin labels: Chem. Rev., 78, 37 (1978); Recent advances in the chemistry of nitroxides and their applications in spin labelling: J. Sci. Ind. Res., 54, 623 (1995). For a brief feature on derived oxoammonium salts, see: Synlett, 1757 (2003).
Recommended as a stabilizer (antioxidant) for the protection of unsaturated fatty acids and their derivatives: J. Am. Chem. Soc., 101, 6748 (1979).
żamoj?, K.; Wiczk, W.; Zaborowski, B.; Jacewicz, D.; Chmurzyński, L. Analysis of Fluorescence Quenching of Coumarin Derivatives by 4-Hydroxy-TEMPO in Aqueous Solution. J. Fluoresc. 2014, 24 (3), 713-718.
żamoj?, K.; Zdrowowicz, M.; Wiczk, W.; Jacewicz, D.; Chmurzyński, L. Dihydroxycoumarins as highly selective fluorescent probes for the fast detection of 4-hydroxy-TEMPO in aqueous solution. RSC Adv. 2015, 5 (78), 63807-63812.
Sunkaria, A.; Sharma, D. R.; Wani, W. Y.; Gill, K. D. Attenuation of Dichlorvos-Induced Microglial Activation and Neuronal Apoptosis by 4-Hydroxy TEMPO. Mol. Neurobiol. 2014, 49 (1), 163-175.
Hazard Statements: H302-H318-H373
Harmful if swallowed. Causes serious eye damage. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260-P264b-P270-P280-P301+P312-P305+P351+P338-P310-P314-P330-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Get medical advice/attention if you feel unwell. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant