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N,N-Dimethyl-n-octylamine is used as ion-pairing agent in the quantitative estimation of thiazinamium methylsulphate in a pharmaceutical preparation by HPLC. It acts as a counterion in mobile phase for separation of tetracycline, tetracycline analogs and their potential impurities by reversed-phase ion-pair chromatography. Further, it is used in the study of chiral separations by complexation with proteins in capillary zone electrophoresis. In addition to this, it is used as a mobile phase in direct resolution and quantitation of (R)- and (S)-disopyramide
Modifier for reverse-phase liquid chromatographic separation of amines.
Matsukizono, H.; Endo, T. Synthesis of polyhydroxyurethanes from di(trimethylolpropane) and their application to quaternary ammonium chloride-functionalized films. RSC Adv. 2015, 5 (87), 71360-71369.
Matsunaga, H.; Haginaka, J. Separation of enantiomers on chiral stationary phase based on chicken alpha 1-acid glycoprotein: Effect of silica particle diameters on column performance. J. Chromatogr. A 2014, 1363, 96-100.
Hazard Statements: H227-H301-H314-H318
Combustible liquid. Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P210u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
IF SWALLOWED: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.