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792-74-5 - Dimethyl biphenyl-4,4'-dicarboxylate, 98% - Biphenyl-4'4-dicarboxylic acid dimethyl ester - A12556 - Alfa Aesar

A12556 Dimethyl biphenyl-4,4'-dicarboxylate, 98%

CAS Number
792-74-5
Synonyms
Biphenyl-4'4-dicarboxylic acid dimethyl ester

Size Price ($) Quantity Availability
1g 40.64
5g 154.40
25g 662.40
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Dimethyl biphenyl-4,4'-dicarboxylate, 98%

MDL
MFCD00017201
EINECS
212-341-4

Chemical Properties

Formula
C16H14O4
Formula Weight
270.29
Melting point
212-216°
Solubility
Insoluble in water.

Applications

Dimethyl biphenyl-4,4'-dicarboxylate is used as a hepatoprotectant in the treatment of chronic hepatitis. At 250 µg/ml, it has been shown to stimulate JAK/STAT signaling and to induce the expression of interferon-α stimulated genes in a HepG2 cell line. It has been used to study hepatic fibrosis and chronic hepatocellular damage. It appears to normalize alanine aminotransferase (ALT) in cases where levels of ALT are elevated. It may be employed as starting reagent for the synthesis of dimethyl 2-fluoro-and 2,2?-difluorobiphenyl-4,4?-dicarboxylates.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

Seong Soo Joo; Tae Joon Won; Min Jung Kim; Kwang  Woo Hwang; Do Ik Lee. Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG2 2.2.15. Archives of Pharmacal Research. 2006, 29, (5)405-411

V.K. Ol’khovik; A.A.Pap; V.A.Vasilevskii; N.A.Galinovskii; S.N.Tereshko. Synthesis and properties of luminophores derived from fluorinated biphenyls. Russian Journal of Organic Chemistry. 2008, 44, (8)1172-1179

Other References

Beilstein
2055852
Harmonized Tariff Code
2917.39
TSCA
Yes

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