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Acetamide is used as an industrial solvent, plasticizer, wetting and penetrating agent. It is also used for the transamidation of carboxamides in 1,4-dioxane. It finds application in lacquers and soldering flux. Further, it acts as a precursor to thioacetamide.
Useful additive for brominations of acid-sensitive compounds in non-polar solvents since it forms a stable, insoluble 1:1 complex with HBr: Chem. Ber., 82, 275 (1949).
For amidocarbonylation in the presence of carbon monoxide and hydrogen in a route to phenylalanine, see Benzyl chloride, A12481.
D'Amico, F.; Rossi, B.; Camisasca, G.; Bencivenga, F.; Gessini, A.; Principi, E.; Cucini, R.; Masciovecchio, C. Slow-to-fast transition of hydrogen bond dynamics in acetamide hydration shell formation. Phys. Chem. Chem. Phys. 2015, 17 (16), 10987-10992.
Aguilar-Pineda, J. A.; Méndez-Maldonado, G. A.; Núñez-Rojas, E.; Alejandre, J. Parametrisation of a force field of acetamide for simulations of the liquid phase. Mol. Phys. 2015, 113 (17-18), 2716-2724.
Hazard Statements: H351
Suspected of causing cancer.
Precautionary Statements: P201-P202-P281-P308+P313-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Use personal protective equipment as required. IF exposed or concerned: Get medical advice/attention. Dispose of contents/ container to an approved waste disposal plant