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603-76-9 - 1-Methylindole, 98% - A12605 - Alfa Aesar

A12605 1-Methylindole, 98%

CAS Number
603-76-9
Synonyms

Size Price ($) Quantity Availability
10g 32.96
50g 113.30
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1-Methylindole, 98%

MDL
MFCD00005800
EINECS
210-057-5

Chemical Properties

Formula
C9H9N
Formula Weight
131.18
Boiling Point
237-239°
Flash Point
>110°(230°F)
Density
1.048
Refractive Index
1.6065
Sensitivity
Light Sensitive
Solubility
Immiscible with water.

Applications

1-Methylindole is useful for the determination of association constant for the electron-donor-acceptor complexes with 1-(2,4,6-trinitrophenyl) propan-2-one. It acts as a reactant for the preparation of polycyclic derivatives of indoles, bisindole derivatives and pharmaceutically active 2-oxo-1-pyrrolidine analogues. It is also used as a reactant for the preparation of Positron Emission Tomography (PET) imaging agents of protein kinase C (PKC) and glycogen synthase kinase-3 (GSK-3).

Notes

Light sensitive. Store in a cool place. Incompatible with strong oxidizing agents.

Literature References

Lithiation, followed by treatment with tri-n-butyltin chloride gives the indol-2-yltributylstannane, a versatile precursor of 2-substituted indole derivatives; e.g. Stille coupling with alkyl halides gives 2-alkyl derivatives: J. Org. Chem., 59, 4250 (1994):

/n

Dulin, C. C.; Murphy, K. L.; Nolin, K. A. Calcium-catalyzed Friedel-Crafts addition of 1-methylindole to activated cyclopropanes. Tetrahedron Lett. 2014, 55 (38), 5280-5282.

Nematollahi, D.; Hedayatfar, V. Diversity in electrochemical oxidation of dihydroxybenzenes in the presence of 1-methylindole. J. Chem. Sci. 2011, 123 (5), 709-717.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
111026
Harmonized Tariff Code
2933.99
TSCA
Yes

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