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Vitamin of the B complex with hypolipidemic properties occurring in various animal and plant tissues. Required by the body for the formation of coenzymes NAD and NADP.Nicotinic acid is used as an antidyslipidemic agent. It is also used to improve all lipoproteins well above the vitamin requirement and lowers the total cholesterol, "bad" LDL-cholesterol, and triglyceride levels. Further, it is used as a food additive in food industries, cosmetics and pharmaceuticals. In addition to this, it is used in medication, nutrient, enriched flours and in electroplating baths.
Cheng, X.; Hookway, E. S.; Kashima, T.; Oppermann, U.; Galione, A.; Athanasou, N. A. The Role of Calcium and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) in Human Osteoclast Formation and Resorption. Calcif. Tissue Int. 2015, 96 (1), 73-79.
Trabbic, C. J.; Zhang, F.; Walseth, T. F.; Slama, J. T. Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Substituted on the Nicotinic Acid and Adenine Ribosides. Effects on ReceptorMediated Ca2+ Release. J. Med. Chem. 2015, 58 (8), 3593-3610.
Hazard Statements: H319
Causes serious eye irritation.
Precautionary Statements: P280i-P264-P305+P351+P338-P337+P313
Wear eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.