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A12699 1-Adamantanamine hydrochloride, 99%

CAS Number
665-66-7
Synonyms
Amantadine hydrochloride
1-Aminoadamantane hydrochloride

Stock No. Size Price ($) Quantity Availability
A12699-14 25g 58.20
A12699-22 100g 169.00
A12699-36 500g 700.00
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1-Adamantanamine hydrochloride, 99%

MDL
MFCD00074723
EINECS
211-560-2

Chemical Properties

Formula
C10H17N•HCl
Formula Weight
187.71
Melting point
360°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water (50 mg/ml), ethanol (38 mg/ml at 25°C), chloroform (1:18), DMSO (38 mg/ml at 25°C), and methanol

Applications

1-Adamantanamine hydrochloride is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extra pyramidal reactions, and for postherpetic neuralgia. It is also used an NMDA-receptor antagoinst.

Notes

Hygroscopic. Store in cool dry place in tightly closed container. With good ventilation. Store away from oxidizing agent and water/moisture.

Literature References

A.W. Galbraith; J.S. Oxford; G.C. Schild; G.I. Watson. Protective Effect Of 1-Adamantanamine Hydrochloride On Influenza A2 Infections In The Family Environment. The Lancet. 1969, 294(7629),1026-1028.

W. L. Davies; R. R. Grunert; R. F. Haff; J. W. McGahen; E. M. Neumayer; M. Paulshock; J. C. Watts; T. R. Wood; E. C. Hermann; C. E. Hoffmann. Antiviral Activity of 1-Adamantanamine (Amantadine). Science . 1964, 144(3620),862-863.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H314-H335-H360

Harmful if swallowed. Causes severe skin burns and eye damage. May cause respiratory irritation. May damage fertility or the unborn child.

Precautionary Statements: P201-P202-P260-P264b-P270-P271-P281-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,374
Beilstein
4198854
Harmonized Tariff Code
2921.30
TSCA
Yes
RTECS
AU4375000

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