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Ethylene chlorophosphite acts as a phosphitylating agent involved in the preparation of phosphocholine and spirophosphoranes. For example, it is used in the phosphorylation of p-tert-butyl(thia)calixarenes.
Peptide coupling reagent via the mixed anhydride; see Appendix 6: J. Am. Chem. Soc., 72, 5491 (1950).
In conjunction with triethyl phosphite, dehydrates primary carboxamides to nitriles, which has been applied in peptide chemistry: J. Am. Chem. Soc., 88, 2025 (1966).
Used in the coupling of arylamines with CS2 to give diarylthioureas: Rev. Roum. Chim., 29, 329 (1984).
Stoikov, I. I.; Mostovaya, O. A.; Yantemirova, A. A.; Antipin, I. S.; Konovalov, A. I. Phosphorylation of p-tert-butyl (thia) calixarenes by ethylene chlorophosphite. Mendeleev Commun. 2012, 22 (1), 21-22.
Kibardina, L. K.; Dobrynin, A. B.; Burilov, A. R.; Pudovik, M. A. Reaction of N, N-Bis (2-hydroxy-1-naphthaldehyde)-ethylenediimine with ethylene chlorophosphite. Russ. J. Gen. Chem. 2011, 81 (8), 1728-1729.
Hazard Statements: H227-H314-H318
Combustible liquid. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P210u-P260u-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.