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Di-tert-butyl malonate, is used as a pharmaceutical intermediate. it can be used to produce Diazomalonsaeure-di-tert-butylester at the ambient temperature. It will need reagents cesium carbonate, p-toluenesulfonyl azide and solvent tetrahydrofuran with the reaction time of 1 hour. T
AL McCloskey.; GS Fonken.; RW Kluiber. Di-tert-butyl Malonate. organic chemistry. 200373, (1) , 49-57.
DY Kim.;SC Huh.; SM Kim. Enantioselective Michael reaction of malonates and chalcones by phase-transfer catalysis using chiral quaternary ammonium salt. Tetrahedron Letters. 200142, (36) , 6299-6301.
Alternative to Diethyl malonate, A15468, permitting removal of the t-butyl groups and decarboxylation by thermolysis in the presence of mild acid: J. Am. Chem. Soc., 74, 831 (1952). In the presence of Cu(OAc)2, condenses with paraformaldehyde to form the useful electrophilic alkene, di-t-butyl methylenemalonate: J. Org. Chem., 48, 3603 (1983), which is more stable than the ethyl or methyl esters, and can be stored for some weeks at room temperature. For references to use of methylenemalonic esters in Michael addition and cycloaddition reactions, see: Org. Synth. Coll., 7, 142 (1990).
Hazard Statements: H227-H317
Combustible liquid. May cause an allergic skin reaction.
Precautionary Statements: P210u-P261-P280a-P363-P403+P235-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. Wash contaminated clothing before reuse. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.