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103-71-9 - Phenyl isocyanate, 98+% - A12808 - Alfa Aesar

A12808 Phenyl isocyanate, 98+%

CAS Number
103-71-9
Synonyms

Size Price ($) Quantity Availability
5g 19.26
100g 27.27
250g 54.00
1000g 175.50
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Phenyl isocyanate, 98+%

MDL
MFCD00001994
EINECS
203-137-6

Chemical Properties

Formula
C7H5NO
Formula Weight
119.12
Melting point
-33°
Boiling Point
62-64°/11mm
Flash Point
51°(123°F)
Density
1.094
Refractive Index
1.5360
Sensitivity
Moisture Sensitive
Solubility
Miscible with ether.

Applications

Phenyl isocyanate is used with triethylamine in order to activate nitro groups to undergo 1,3-dipolar cycloaddition. It is also employed in the preparation of chemically modified cellulose paper. Further, it is used in the preparation of functionalized graphene oxide nanoplatelets. In addition to this, it reacts with ethyl alcohol to prepare ethyl alfa,gamma-diphenylallophanate and small amount of phenyl isocyanate dimer.

Notes

Store in a cool place. Incompatible with strong oxidizing agents, water, moisture, alcohols, amines, strong bases and strong acids.

Literature References

For general reactions of isocyanates, see Appendix 3.

Can be used, in the presence of pyridine, to protect alcohols as N-phenylcarbamates: J. Am. Chem. Soc., 94, 3578 (1972), e.g. selective protection of primary OH groups in pyranosides; cleavage by reduction with LiAlH4: Tetrahedron Lett., 28, 4165 (1987). The group can also be cleaved by refluxing with NaOMe: Acta Chem. Scand., 15, 87, 96 (1961). Amines may also be protected as N-phenylcarbamates: Tetrahedron Lett., 1935 (1977).

Forms ureas by reaction with amines; e.g. Tris(2-aminoethyl)­amine, B21789, gives a molecule containing three urea groups which was used in studies of spacers for phosphate receptors: Chem. Lett., 759 (1995). Reaction with 4-aminobenzimidazole derivatives has been used in the synthesis of 1-phenylxanthine derivatives: Synthesis, 855 (1995).

In the presence of triethylamine, dehydrates nitroalkanes to nitrile oxides, which can undergo 1,3-dipolar cycloadditions: J. Am. Chem. Soc., 82, 5339 (1960); Synthesis, 757 (1980). Similarly, aldoximes are converted to nitriles: J. Org. Chem., 26, 782 (1961).

Conversion to diphenylcarbodiimide can be catalyzed by 3-Methyl-1-phenyl-2-phospholene 1-oxide, A11792: Org. Synth. Coll., 5, 501 (1973).

Seifi, M.; Ebrahimipour, S. Y.; Simpson, J.; Dusek, M.; Eigner, V.; Sheibani, H. Combination of Pyridinium and Isoquinolinium Ylides with Phenylisocyanate and Isothiocyanates: Synthesis, Characterisation, and X-Ray Crystal Structures of Mesoionic Monosubstituted 3-Oxo-Propanamides or Thioamides. Aust. J. Chem. 2015, 68 (10), 1577-1582.

Mali'n, T. J.; Lindberg, S.; Astot, C. Novel glutathione conjugates of phenyl isocyanate identified by ultra-performance liquid chromatography/electrospray ionization mass spectrometry and nuclear magnetic resonance. J. Mass Spectrom. 2014, 49 (1), 68-79.

GHS Hazard and Precautionary Statements

Hazard Statements: H330-H302-H317-H334-H314-H318-H226

Fatal if inhaled. Harmful if swallowed. May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour.

Precautionary Statements: P210-P260-P284-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,7296
Beilstein
471391
Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2929.10
TSCA
Yes
RTECS
DA3675000

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