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1,4-Dimethoxybenzene is used as Pharmaceutical Intermediate. It is used in some paints and as a diazo dye. It is also used in perfumes and flavors in order to its floral odor. In addition, it is used on greasy skin, and with sulfur to treat acne, or as a dandruff treatment.
T. H. Goodwin.; M. Przybylska.; J. M. Robertson. The crystal and molecular structure of 1:4-dimethoxybenzene. Acta Cryst. 1950, 3 279-284.
Dötterl Stefan.; Ulrike Füssel.; Andreas Jürgens.; Gregor Aas. 1, 4-Dimethoxybenzene, a floral scent compound in willows that attracts an oligolectic bee. Journal of chemical ecology. 2005, 31 (12), 2993-2998.
In contrast to the 1,3-isomer (see preceding entry), direct dilithiation with n-BuLi/TMEDA was successful, giving, with TMS chloride, the 2,5-disilyl derivative in 68% yield: J. Org. Chem., 49, 4657 (1984).
1,4-Dimethoxybenzene and its simple derivatives undergo anodic oxidation in methanol, to give bis-acetals of benzoquinones. For experimental details, see: Org. Synth. Coll., 6, 971 (1988). For a review of the chemistry of these bis-acetals and of the mono-acetals obtained by partial hydrolysis, see: Acc. Chem. Res., 16, 74 (1983).
Hazard Statements: H315
Causes skin irritation.
Precautionary Statements: P280g
Wear protective gloves.