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A12866 3-Hydroxy-4-methoxybenzaldehyde, 98%

CAS Number
621-59-0
Synonyms
3-Hydroxy-p-anisaldehyde
Isovanillin

Stock No. Size Price ($) Quantity Availability
A12866-06 5g 16.00
A12866-14 25g 55.60
A12866-22 100g 153.00
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3-Hydroxy-4-methoxybenzaldehyde, 98%

MDL
MFCD00003369
EINECS
210-694-9

Chemical Properties

Formula
C8H8O3
Formula Weight
152.15
Melting point
112-116°
Boiling Point
179°/15mm
Flash Point
>110°(230°F)
Density
1.20
Storage & Sensitivity
Air Sensitive. Light Sensitive. Ambient temperatures.
Solubility
Soluble in acetone and methanol.

Applications

3-Hydroxy-4-methoxybenzaldehyde acts as a precursor for the stereoselective synthesis of the anticancer drug (Z)-combretastatin A-4 and glycitein. It also used as an important raw material for the preparation of morphine. Further, it is involved in the preparation of Schiff- bases by reacting with furan-2-carboxylic acid hydrazide and thiophene-2-carboxylic acid hydrazide. In addition to this, it is used to prepare (Z)-2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one by reacting with with1-azabicyclo[2.2.2]octan-3-one.

Notes

Air sensitive. Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

Literature References

Aggarwal, R. L.; Di Cecca, S.; Farrar, L. W.; Shabshelowitz, A.; Jeys, T. H. Sensitive Detection and Identification of Isovanillin Aerosol Particles at the pg/cm3 Mass Concentration Level Using Raman Spectroscopy. Aerosol Sci. Tech. 2015, 49 (9), 753-756.

Vusovich, O. V.; Lapin, I. N.; Svetlichnyi, V. A.; Sul’timova, N. B.; Tchaikovskaya, O. N. Comparison of Vanillin and Isovanillin Photolysis in Aqueous Solutions. Russ. Phys. J. 2014, 56 (11), 1287-1291.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1073021
Harmonized Tariff Code
2912.49
TSCA
Yes
RTECS
CU6540000

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