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Ethyl methanesulfonate is used as mutagen for both mammalian and plant cells. It finds application as a model alkylating agent in the study of deoxyribonucleic acid (DNA) repair processes.
Hartwig, B.; James, G. V.; Konrad, K.; Schneeberger, K.; Turck, F. Fast isogenic mapping-by-sequencing of ethyl methanesulfonate-induced mutant bulks. Plant Physiol. 2012, 160 (2), 591-600.
Gunther, W. C.; Coffing, S. L.; Dickinson, D. A.; Engel, M. E.; Fiedler, R. D.; O'Lone, S. D.; Dobo, K. L. Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate. Environ Mol Mutagen 2014, 55 (6), 492-499.
Hazard Statements: H302-H315-H319-H335-H340-H351
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause genetic defects. Suspected of causing cancer.
Precautionary Statements: P201-P202-P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P337+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant