1-Methylisatin is used as a reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones, for regioselective preparation of spirocyclic oxindole-butenolides, for synthesis of spiro-oxindoles, for preparation of unsymmetrical oxindoles, for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction, for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents.
Paulami Mandal.; Tapan Ganguly. Fluorescence Spectroscopic Characterization of the Interaction of Human Adult Hemoglobin and Two Isatins, 1-Methylisatin and 1-Phenylisatin: A Comparative Study. J. Phys. Chem. 2009, 113 (45), 14904-14913.
Idan Chiyanzu.; Elizabeth Hansell.; Jiri Gut.; Philip J. Rosenthal.; James H. McKerrow.; Kelly Chibale. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorganic & Medicinal Chemistry Letters. 2003, 13 (20), 3527-3530.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P260-P201-P280g-P304+P340-P405-P501a