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2-Bromopropane serves as an alkylating agent in organic synthesis. It is also used as an intermediate to form alkylated amines and alkylated metallic compounds. Further, it acts as a solvent for industrial cleaning, degreasing, metal processing and finishing, electronics, aerospace and aviation, aerosols, textiles, adhesives and inks. In addition, it is used for introducing the isopropyl functional group in organic synthesis.
Can be used, (K2CO3 in DMF), to protect phenolic OH groups as their isopropyl ethers, more stable than benzyl ethers to Lewis acids: J. Chem. Soc., Perkin 1, 2593 (1979).
Vatsal, A.; Zinjarde, S. S.; Kumar, A. R. Yarrowia lipolytica NCIM 3589, a tropical marine yeast, degrades bromoalkanes by an initial hydrolytic dehalogenation step. Biodegradation 2015, 26 (2), 127-138.
Simonetti, S. O.; Larghi, E. L.; Kaufman, T. S. Alternate and Step-Economic Synthesis of the β-Methylstyrene Chelating Pre-ligand of the Hoveyda-Grubbs II Catalyst. Org. Prep. Proced. Int. 2015, 47 (3), 227-231.
Hazard Statements: H225-H360-H373
Highly flammable liquid and vapour. May damage fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: P210-P260-P201-P303+P361+P353-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.