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673-22-3 - 2-Hydroxy-4-methoxybenzaldehyde, 98% - 2-Hydroxy-p-anisaldehyde - 4-Methoxysalicylaldehyde - A12971 - Alfa Aesar

A12971 2-Hydroxy-4-methoxybenzaldehyde, 98%

CAS Number
673-22-3
Synonyms
2-Hydroxy-p-anisaldehyde
4-Methoxysalicylaldehyde

Size Price ($) Quantity Availability
1g 17.42
5g 58.50
25g 164.42
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2-Hydroxy-4-methoxybenzaldehyde, 98%

MDL
MFCD00003327
EINECS
211-604-0

Chemical Properties

Formula
C8H8O3
Formula Weight
152.15
Melting point
40-44°
Flash Point
>110°(230°F)
Sensitivity
Air Sensitive
Solubility
Solubility in methanol is almost transparent. Insoluble in water.

Applications

It is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.

Notes

Air sensitive. Store away from oxidizing agents, bases and air/oxygen. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas.

Literature References

Basak S, et al. Synthesis, crystal structures and fluorescence properties of two new di-and polynuclear Cd (II) complexes with N2O donor set of a tridentate Schiff base ligand.Polyhedron.,2008,27(4), 1193-1200.

Jihua Wang, et al. Antimicrobial and antioxidant activities of the root bark essential oil of Periploca sepium and its main component 2-hydroxy-4-methoxybenzaldehyde.Molecules.,2010,15(8), 5807-5817 .

I Kubo and I Kinst-Hori. 2-Hydroxy-4-methoxybenzaldehyde: a potent tyrosinase inhibitor from African medicinal plants.lanta Med.,1999,65(1), 19-22.

Condensation with t-butyl acrylate results in cyclization to t-butyl 7-methoxychromene-3-carboxylate: J. Med. Chem., 36, 3580 (1993):

With (Ethoxycarbonyl­methyl­ene)­triphenyl­phosphorane, A12896, in N,N-diethylaniline cyclization to 7-methoxycoumarin occurs: Heterocycles, 39, 613 (1994).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1072443
Harmonized Tariff Code
2912.49
TSCA
Yes
RTECS
BZ2810000

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