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14268-66-7 - 3,4-(Methylenedioxy)aniline, 98+% - 5-Amino-1,3-benzodioxole - 1,3-Benzodioxol-5-amine - A12975 - Alfa Aesar

A12975 3,4-(Methylenedioxy)aniline, 98+%

CAS Number
14268-66-7
Synonyms
5-Amino-1,3-benzodioxole
1,3-Benzodioxol-5-amine

Size Price ($) Quantity Availability
10g 24.82
50g 72.49
250g 274.40
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3,4-(Methylenedioxy)aniline, 98+%

MDL
MFCD00005832
EINECS
238-161-6

Chemical Properties

Formula
C7H7NO2
Formula Weight
137.14
Melting point
40-45°
Boiling Point
144°/16mm
Flash Point
142°(287°F)
Sensitivity
Air & Light Sensitive
Solubility
Slightly soluble in water.

Applications

3,4-(Methylenedioxy)aniline is an pharmaceutically important aniline derivative. It undergoes N-alkylation with cyclic secondary alkylamines in the presence of Shvo catalyst to yield N-arylpyrrolidines. 3,4-(Methylenedioxy)aniline was used in the synthesis of γ-glutamylanilides.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible to strong acids, acid chlorides, acid anhydrides. Air & Light Sensitive. Stable under recommended storage conditions.

Literature References

SJ Tu.; XD Cao.; WJ Hao.; XH Zhang .; S Yan. An efficient and chemoselective synthesis of benzo [e][1, 4] thiazepin-2 (1 H, 3 H, 5 H)-ones via a microwave-assisted multi-component reaction in water. Organic & Biomolecular Chemistry. 20097, (3) , 557-563.

MJ Luzzio.; JM Besterman.; DL Emerson. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. J. Med. Chem. 199538, (3) , 395-401.

GHS Hazard and Precautionary Statements

Hazard Statements: H331-H302-H312-H315-H319

Toxic if inhaled. Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P311-P362-P301+P312-P312-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
4919
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2932.99
TSCA
Yes

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