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tert-Butyl chloride plays an important role as a starting material to perform nucleophilic substitution reactions in order to prepare alcohol and alkoxides salts. It is used as an alkylating agent for the introduction of tert-butyl group and is also involved in Friedel-Crafts reactions. It is employed as an intermediate for the synthesis of agrochemicals and pharmaceuticals.
Stathi, P.; Deligiannakis, Y.; Avgouropoulos, G.; Louloudi, M. Efficient H 2 production from formic acid by a supported iron catalyst on silica. Appl. Catal., A 2015, 498, 176-184
Sedov, I. A.; Stolov, M. A.;Solomonov, B. N. tert-Butyl chloride as a probe of the solvophobic effects. Fluid Phase Equilib. 2014, 382 164-168.
Hazard Statements: H225
Highly flammable liquid and vapour.
Precautionary Statements: P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant