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3,4-Dimethylphenylhydrazine hydrochloride, is used as a reactant with ethyl 3-ethoxy-2-ethoxycarbonylprop-2-enoate to produce 2-(3,4-dimethyl-phenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester. This reaction will need reagent K2CO3, and the menstruum ethanol.
JA Markwalder.; MR Arnone.; PA Benfield. Synthesis and biological evaluation of 1-aryl-4, 5-dihydro-1 H-pyrazolo [3, 4-d] pyrimidin-4-one inhibitors of cyclin-dependent kinases. J. Med. Chem.200447 (24), 5894-5911.
H Li.; L Cai.; J Li.; Y Hu.; P Zhou.; J Zhang. Novel coumarin fluorescent dyes: Synthesis, structural characterization and recognition behavior towards Cu (II) and Ni (II). Dyes and Pigments. 2011, 91 (3), 309-316.
Hazard Statements: H301-H315-H319-H335
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.