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N-Acetyl-D-glucosamine is used in the identification and characterization of N-acetyl-beta-D-hexoaminidase. It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
Bobbink, F. D.; Zhang, J.; Pierson, Y.; Chen, X.; Yan, N. Conversion of chitin derived N-acetyl-D-glucosamine (NAG) into polyols over transition metal catalysts and hydrogen in water. Green Chem. 2015, 17 (2), 1024-1031.
Mutter, S. T.; Zielinski, F.; Cheeseman, J. R.; Johannessen, C.; Popelier, P. L.; Blanch, E. W. Conformational dynamics of carbohydrates: Raman optical activity of D-glucuronic acid and N-acetyl-D-glucosamine using a combined molecular dynamics and quantum chemical approach. Phys. Chem. Chem. Phys. 2015, 17 (8), 6016-6027.