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1-Chloro-3-fluorobenzene used as medicine and liquid crystal intermediates.
M.Onda; T.Odaka; H.Miyazaki; M. Mori; I.Yamaguchi; Y.Niide. Microwave Spectrum, Quadrupole Coupling Constant Tensors, and Dipole Moments of 1-Chloro-3-Fluorobenzene. Journal of Molecular Spectroscopy. 1994, 165, (2),426-432
Antonio Ramirez; John Candler; Crystal G.Bashore; Michael C.Wirtz, Jotham W.Coe; David B.Collum. Formation of benzynes from 2,6-dihaloaryllithiums: mechanistic basis of the regioselectivity. Journal of the American Chemical Society. 2004, 126, (45),14700-14701
Can be lithiated with n-BuLi at the 2-position. Reaction of the metallated species with CO2 gives 2-chloro-6-fluorobenzoic acid in 93% yield: Tetrahedron Lett., 37, 6551 (1996).
Hazard Statements: H225-H315-H319-H335
Highly flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P363-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant