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A13141 N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 97%

CAS Number
24589-78-4
Synonyms
MSTFA
N-Trimethylsilyl-N-methyltrifluoroacetamide

Stock No. Size Price ($) Quantity Availability
A13141-06 5g 49.80
A13141-14 25g 153.00
A13141-22 100g 483.00
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N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 97%

MDL
MFCD00000411
EINECS
246-331-6

Chemical Properties

Formula
C6H12F3NOSi
Formula Weight
199.25
Boiling Point
130-132°
Flash Point
25°(77°F)
Density
1.076
Refractive Index
1.3800
Storage & Sensitivity
Moisture Sensitive. Ambient temperatures.
Solubility
Immiscible with water.

Applications

N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone.

Notes

Moisture sensitive. Store in a cool place. Incompatible with strong oxidizing agents and strong acids.

Literature References

Powerful silylating agent for a wide range of functional groups: J. Chromat., 115, 591 (1975); 134, 387 (1977); Chromatographia, 9, 440 (1976). See Appendix 4.

Cabanelas, D. G.; Wright, L. P.; Paetz, C.; Onkokesung, N.; Gershenzon, J.; Concepción, M. R.; Phillips, M. A. The diversion of 2-C-methyl-d-erythritol-2, 4-cyclodiphosphate from the 2-C-methyl-d-erythritol 4-phosphate pathway to hemiterpene glycosides mediates stress responses in Arabidopsis thaliana. Plant J. 2015, 82 (1), 122-137.

Wong, A. S. Y.; Ho, E. N. M.; Wan, T. S. M.; Lam, K. K. H.; Stewart, B. D. Metabolic studies of oxyguno in horses. Anal. Chim. Acta 2015, 891, 190-202.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P261-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1941550
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2931.90
TSCA
Yes
RTECS
AC9800000

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