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A13146 2-Hydroxyisobutyric acid, 99% (dry wt.), water <2%

CAS Number
594-61-6
Synonyms
2-Hydroxy-2-methylpropionic acid
2-Methyllactic acid

Stock No. Size Price ($) Quantity Availability
A13146-14 25g 27.40
A13146-22 100g 81.40
A13146-36 500g 372.00
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2-Hydroxyisobutyric acid, 99% (dry wt.), water <2%

MDL
MFCD00004459
EINECS
209-848-8

Chemical Properties

Formula
C4H8O3
Formula Weight
104.11
Melting point
77-80°
Boiling Point
114°/12mm
Density
1.24
Storage & Sensitivity
Hygroscopic. Ambient temperatures.
Solubility
Soluble in water, ether, alcohol, methanol and hot benzene.

Applications

2-Hydroxyisobutyric acid is used as an electrolyte in the separation of the metal ions by on-line cyclic voltammetry. It is also used as a building block for the synthesis of polymers. Its conjugate base, 2-hydroxybutyrate is utilized to catabolize L-threonine as well as synthesize glutathione. Further, it is used as an indicator for the early detection insulin resistance in non-diabetic subjects.

Notes

Incompatible with oxidizing agents, bases and reducing agents.

Literature References

Przybylski, D.; Rohwerder, T.; Dilßner, C.; Maskow, T.; Harms, H.; Müller, R. H. Exploiting mixtures of H2, CO2, and O2 for improved production of methacrylate precursor 2-hydroxyisobutyric acid by engineered Cupriavidus necator strains. Appl. Microbiol. Biotechnol. 2015, 99 (5), 2131-2145.

Lee, J.; Jung, Y.; Park, J. Y.; Lee, S. H.; Ryu, D. H.; Hwang, G. S. LC/MS-based polar metabolite profiling reveals gender differences in serum from patients with myocardial infarction. J. Pharm. Biomed. Anal. 2015, 115, 475-486.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H318-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1744739
Harmonized Tariff Code
2918.19
TSCA
Yes

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