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421-53-4 - Trifluoroacetaldehyde hydrate, tech., ca 75% in water - 2,2,2-Trifluoro-1,1-ethanediol - A13234 - Alfa Aesar

A13234 Trifluoroacetaldehyde hydrate, tech., ca 75% in water

CAS Number
421-53-4
Synonyms
2,2,2-Trifluoro-1,1-ethanediol

Size Price ($) Quantity Availability
10g 82.71
50g 310.03
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Trifluoroacetaldehyde hydrate, tech., ca 75% in water

MDL
MFCD00167359
EINECS
207-006-4

Chemical Properties

Formula
C2H3F3O2
Formula Weight
116.04(anhy)
Boiling Point
104-106°
Flash Point
None
Density
1.44
Solubility
Soluble in water.

Applications

One general application of trifluoroacetaldehyde is the preparation of trifluoroethylamino derivatives via reductive amination reaction. This synthesis includes the formation of the corresponding N,O-acetal intermediates followed by their reduction using NaBH4 or 2-picoline borane complex, affording the target trifluoroethylamino compounds in moderate to good yields. Another general application of trifluoroacetaldehyde is the synthesis of chiral α-substituted trifluoroethylamino compounds.

Notes

Store at room temperature. Incompatible with oxidizing agents. Keep in cool place.

Literature References

G. K. Surya Prakash.; Zhe Zhang.; Fang Wang.; Socrates Munoz.; George A. Olah. Nucleophilic Trifluoromethylation of Carbonyl Compounds: Trifluoroacetaldehyde Hydrate as a Trifluoromethyl Source.J. Org. Chem. 2013, 78 (7),3300-3305 .

Mauno M. Airaksinen.; Per H. Rosenberg.; Tapani Tammisto. A Possible Mechanism of Toxicity of Trifluoroethanol and Other Halothane Metabolites.Acta Pharmacologica et Toxicologica. 1970, 28 (4),299-304 .

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H318-H315-H302-H317-H335

Highly flammable liquid and vapour. Causes serious eye damage. Causes skin irritation. Harmful if swallowed. May cause an allergic skin reaction. May cause respiratory irritation.

Precautionary Statements: P210-P261-P280-P303+P361+P353-P305+P351+P338-P304+P340-P310-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2905.59
TSCA
Yes
RTECS
KI2850000

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