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One general application of trifluoroacetaldehyde is the preparation of trifluoroethylamino derivatives via reductive amination reaction. This synthesis includes the formation of the corresponding N,O-acetal intermediates followed by their reduction using NaBH4 or 2-picoline borane complex, affording the target trifluoroethylamino compounds in moderate to good yields. Another general application of trifluoroacetaldehyde is the synthesis of chiral α-substituted trifluoroethylamino compounds.
G. K. Surya Prakash.; Zhe Zhang.; Fang Wang.; Socrates Munoz.; George A. Olah. Nucleophilic Trifluoromethylation of Carbonyl Compounds: Trifluoroacetaldehyde Hydrate as a Trifluoromethyl Source.J. Org. Chem. 2013, 78 (7),3300-3305 .
Mauno M. Airaksinen.; Per H. Rosenberg.; Tapani Tammisto. A Possible Mechanism of Toxicity of Trifluoroethanol and Other Halothane Metabolites.Acta Pharmacologica et Toxicologica. 1970, 28 (4),299-304 .
Hazard Statements: H225-H302-H315-H318-H317-H335
Highly flammable liquid and vapour. Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause an allergic skin reaction. May cause respiratory irritation.
Precautionary Statements: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.