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A13240 Colchicine, 95% (dry wt.)

CAS Number
64-86-8
Synonyms

Stock No. Size Price ($) Quantity Availability
A13240-03 1g 87.20
A13240-06 5g 298.00
A13240-14 25g 1121.00
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Colchicine, 95% (dry wt.)

MDL
MFCD00078484
EINECS
200-598-5

Chemical Properties

Formula
C22H25NO6
Formula Weight
399.44
Melting point
ca 150° dec.
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubility
Soluble in water and alcohol. Sparingly soluble in ether.

Applications

Colchicine is used as an anti-inflammatory agent for long-term treatment of behçet's disease. It is used for constipation-predominant irritable bowel syndrome in women, and for treatment of severe or persistent aphthous stomatitis (canker sores).

Notes

Incompatible with strong oxidizing agents and mineral acids.

Literature References

Hwang, D.; Wang, J.; Li, W.; Miller, D. D. Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents. ACS Med. Chem. Lett. 2015, 6 (9), 993-997.

Kuroiwa, K.; Ishii, H.; Matsuno, K.; Asai, A.; Suzuki, Y. Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents. ACS Med. Chem. Lett. 2015, 6 (3), 287-291.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H340

Fatal if swallowed. May cause genetic defects.

Precautionary Statements: P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2471
Beilstein
2228813
Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2939.80
TSCA
Yes
RTECS
GH0700000

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