Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

109-04-6 - 2-Bromopyridine, 99% - A13241 - Alfa Aesar

A13241 2-Bromopyridine, 99%

CAS Number
109-04-6
Synonyms

Size Price ($) Quantity Availability
25g 27.90
100g 72.36
250g 127.88
500g 227.20
Add to Cart Add to Quote Request View Item

2-Bromopyridine, 99%

MDL
MFCD00006219
EINECS
203-641-6

Chemical Properties

Formula
C5H4BrN
Formula Weight
158.00
Boiling Point
192-194°
Flash Point
97°(207°F)
Density
1.625
Refractive Index
1.5720
Solubility
Slightly miscible with water.

Applications

2-Bromopyridine is used in the preparation of a variety of biologically active compounds like antimalarial agents. It is also used to prepare beta-adrenoceptor agonist.

Notes

Keep away from heat, sparks, and flame. Hygroscopic. Incompatible with strong oxidizing agents, strong acids and acid chlorides.

Literature References

Bromopyridines can be converted to the Grignards by Mg exchange with i-PrMgCl: Tetrahdron Lett., 40, 4339 (1999).

Reaction with n-BuLi gives 2-lithio-pyridine. Subsequent reaction at low temperatures with PCl3 gives, as the major product, 2,2'-bipyridine, along with a low yield of the expected tris(2-pyridyl)phosphine. POCl3 or SOCl2 also promote the symmetrical coupling reaction: Heteroatom. Chem., 5, 409 (1994). In contrast, reaction with LDA in THF at -78o results in lithiation at the 3-position, giving access to 3-substituted 2-bromopyridines: Synthesis, 235, 237 (1982). See also: Org. Lett., 3, 835 (2001).

Kathiravan, S.; Ghosh, S.; Hogarth, G.; Nicholls, I. A. Copper catalysed amidation of aryl halides through chelation assistance. Chem. Commun. 2015, 51 (23), 4834-4837.

Liu, C.; Li, X.; Liu, C.; Wang, X.; Qiu, J. Palladium-catalyzed ligand-free and efficient Suzuki-Miyaura reaction of heteroaryl halides with MIDA boronates in water. RSC Adv. 2015, 5 (67), 54312-54315.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H310-H315-H319-H335

Toxic if swallowed. Fatal in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P280h-P305+P351+P338-P309-P310

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Other References

Beilstein
105789
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2933.39
TSCA
Yes
RTECS
US3850000

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware