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A13249 2,4-Difluoro-1-nitrobenzene, 98%

CAS Number
446-35-5
Synonyms

Stock No. Size Price ($) Quantity Availability
A13249-14 25g 32.00
A13249-22 100g 86.20
A13249-36 500g 311.00
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2,4-Difluoro-1-nitrobenzene, 98%

MDL
MFCD00007050
EINECS
207-167-0

Chemical Properties

Formula
C6H3F2NO2
Formula Weight
159.09
Melting point
9-10°
Boiling Point
203-204°
Flash Point
90°(194°F)
Density
1.450
Refractive Index
1.5130
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water.

Applications

2,4-Difluoronitrobenzene has been used in the synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction, (±)-horsfiline and resin-bound-2-arylaminobenzimidazoles.

Notes

Store at room temperature. Incompatible with oxidizing agents. Ensure adequate ventilation.

Literature References

W. Cameron Black .; Benoit Guay.; Frank Scheuermeyer. Metalation of Nitroaromatics with in Situ Electrophiles. J. Org. Chem. 1997, 62 (3), 758-760 .

Guanyu Yang.; Qiaohong Zhang .; Hong Miao.; Xinli Tong.; Jie Xu. Selective Organocatalytic Oxygenation of Hydrocarbons by Dioxygen Using Anthraquinones and N-Hydroxyphthalimide.Org. Lett. 2005, 7 (2),263-266 .

Nucleophilic displacement of the activated fluorines with 2-ethyl-4-methylimidazole occurs predominantly at the 2-position, or, under more forcing conditions, at both 2- and 4-positions: J. Med. Chem., 34, 2671 (1991).

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H301-H311-H315-H319-H331-H335

Combustible liquid. Toxic if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. Toxic if inhaled. May cause respiratory irritation.

Precautionary Statements: P210-P235-P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P311-P312-P330-P332+P313-P337+P313-P361-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2048034
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2904.99
TSCA
Yes
RTECS
CZ5730000

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