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446-35-5 - 2,4-Difluoro-1-nitrobenzene, 98% - A13249 - Alfa Aesar

A13249 2,4-Difluoro-1-nitrobenzene, 98%

CAS Number
446-35-5
Synonyms

Size Price ($) Quantity Availability
25g 27.30
100g 73.34
500g 258.14
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2,4-Difluoro-1-nitrobenzene, 98%

MDL
MFCD00007050
EINECS
207-167-0

Chemical Properties

Formula
C6H3F2NO2
Formula Weight
159.09
Melting point
9-10°
Boiling Point
203-204°
Flash Point
90°(194°F)
Density
1.450
Refractive Index
1.5130
Solubility
Insoluble in water.

Applications

2,4-Difluoronitrobenzene has been used in the synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction, (±)-horsfiline and resin-bound-2-arylaminobenzimidazoles.

Notes

Store at room temperature. Incompatible with oxidizing agents. Ensure adequate ventilation.

Literature References

W. Cameron Black .; Benoit Guay.; Frank Scheuermeyer. Metalation of Nitroaromatics with in Situ Electrophiles. J. Org. Chem. 1997, 62 (3), 758-760 .

Guanyu Yang.; Qiaohong Zhang .; Hong Miao.; Xinli Tong.; Jie Xu. Selective Organocatalytic Oxygenation of Hydrocarbons by Dioxygen Using Anthraquinones and N-Hydroxyphthalimide.Org. Lett. 2005, 7 (2),263-266 .

Nucleophilic displacement of the activated fluorines with 2-ethyl-4-methylimidazole occurs predominantly at the 2-position, or, under more forcing conditions, at both 2- and 4-positions: J. Med. Chem., 34, 2671 (1991).

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H311-H331-H315-H319-H335-H373-H227

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause damage to organs through prolonged or repeated exposure. Combustible liquid.

Precautionary Statements: P210-P260-P261-P280-P301+P310-P305+P351+P338-P361-P304+P340-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2048034
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2904.90
TSCA
Yes
RTECS
CZ5730000

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