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A13285 Formic acid, 97%

CAS Number
64-18-6
Synonyms

Stock No. Size Price ($) Quantity Availability
A13285-36 500g 30.30
A13285-0E 2500g 68.60
A13285-0C 10000g 233.00
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Formic acid, 97%

MDL
MFCD00003297
EINECS
200-579-1

Chemical Properties

Formula
CH2O2
Formula Weight
46.03
Melting point
7-9°
Boiling Point
100-101°
Flash Point
50°(156°F)
Density
1.220
Refractive Index
1.3710
Storage & Sensitivity
Hygroscopic. Store under Nitrogen. Ambient temperatures.
Solubility
Miscible with water. Partially miscible with toluene, xylene and benzene.

Applications

Formic acid is principally used as a preservative antibacterial agent in livestock feed, in dying textiles, tanning leather and electroplating. In the poultry industry, it is sometimes added with feed to kill E. coli bacteria. It acts as a reducing agent for the catalytic reduction of nitrate in water.

Notes

Hygroscopic. Store closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Literature References

Cleaves trityl groups selectively in the presence of benzylidene acetals or TBDMS ethers: Tetrahedron Lett., 27, 579 (1986).

Instead of the unstable formic anhydride, formylations may be carried out with formic acid and acetic anhydride to generate the mixed acetic formic anhydride in situ. For a review, see: Tetrahedron, 46, 1081 (1990). This reagent has been used for the deoxygenation of tertiary amine oxides: Chem. Lett., 1517 (1985).

Dehydration with sulfuric acid can be used to generate CO in situ. Subsequent reaction with tertiary carbocations gives the corresponding carboxylic acid (the Koch-Haaf carboxylation). For examples, see: Org. Synth. Coll., 5, 20, 739 (1973); improved procedure: Synth. Commun., 19, 1945 (1989). 1,4-Diols in which one alcohol is tertiary give -lactones: Chem. Lett., 1187 (1982).

Used in combination with formaldehyde in the Eschweiler-Clarke reductive methylation of amines, the formic acid acting as a hydride donor. Review: Org. React., 5, 290 (1949). For an example, see: Org. Synth. Coll., 3, 723 (1955).

In the presence of Raney nickel alloy, reduces aromatic nitriles to aldehydes in high yield: J. Chem. Soc., 5775 (1965); for list of examples, see: Org. Synth. Coll., 6, 631 (1988).

Hydrogen donor, in combination with Pd on carbon, in catalytic transfer hydrogenations; see, e.g.: Selective reduction of dinitroarenes to nitroanilines: J. Org. Chem., 45, 4992 (1980). Dehalogenation of aryl halides: Synthesis, 876 (1982). Hydrogenation of aromatic rings: Tetrahedron Lett., 33, 7477 (1992). See also Palladium, A12012, Cyclohexene, A11359, and Ammonium formate, A10699. For a comparative mechanistic study of formic acid and formate salts in hydrogenolysis of aryl chlorides, see: J. Org. Chem., 60, 1347 (1995).

In combination with Selenium(IV)­ oxide, 12358, improved results have been obtained in the allylic oxidation of sterically-hindered olefins: Synth. Commun., 24, 29213 (1994).

Rhee, Y. W.; Ha, S. Y.; Masel, R. I. Crossover of formic acid through Nafion membranes. J. Power Sources 2003, 117 (1), 35-38.

Jayashree, R. S.; Spendelow, J. S.; Yeom, J.; Rastogi, C.; Shannon, M. A.; Kenis, P. J. A. Characterization and application of electrodeposited Pt, Pt/Pd, and Pd catalyst structures for direct formic acid micro fuel cells. Electrochim. Acta 2005, 50 (24), 4674-4682.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H302-H314-H331

Flammable liquid and vapour. Harmful if swallowed. Causes severe skin burns and eye damage. Toxic if inhaled.

Precautionary Statements: P210-P233-P240-P241-P242-P243-P261-P264b-P270-P271-P280-P301+P312-P303+P361+P353-P304+P340-P305+P351+P338-P310-P311-P312-P330-P331-P363-P372-P374-P380-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Explosion risk in case of fire. Fight fire with normal precautions from a reasonable distance. Evacuate area. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,4241
Beilstein
1209246
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2915.11
TSCA
Yes
RTECS
LQ4900000

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