Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

75-57-0 - Tetramethylammonium chloride, 97% - A13288 - Alfa Aesar

A13288 Tetramethylammonium chloride, 97%

CAS Number
75-57-0
Synonyms

Size Price ($) Quantity Availability
250g 36.67
1000g 93.60
5000g 337.60
Add to Cart Add to Quote Request View Item

Tetramethylammonium chloride, 97%

MDL
MFCD00011628
EINECS
200-880-8

Chemical Properties

Formula
C4H12ClN
Formula Weight
109.60
Melting point
>300°
Density
1.17
Sensitivity
Hygroscopic
Solubility
Soluble in water. Insoluble in ether, and benzene.

Applications

Tetramethylammonium binds AT-rich DNA polymers while concomitantly abolishing the preferential melting of AT versus GC base pairs. Supplied as 0.2 ?m filtered solution in 18 megohm water. It is employed as a phase transfer catalyst.

Notes

Hygroscopic. Store at room temperature. Incompatible with oxidizing agents. Ensure adequate ventilation.

Literature References

J. Kathleen Buckner.; William L. Jorgensen. Energetics and hydration of the constituent ion pairs of tetramethylammonium chloride. J. Am. Chem. Soc. 1989, 111 (7),2507-2516 .

Anthony G. Dilella.; Savio L.C. Woo. [49] Hybridization of genomic DNA to oligonucleotide probes in the presence of tetramethylammonium chloride.Methods Enzymol. 1987, 152 447-451 .

Thermally-stable phase-transfer catalyst (see Appendix 2) which has been used in nucleophilic displacement reactions of aryl nitro groups with KF in tetramethylene sulfone: J. Org. Chem., 56, 6406 (1991). A detailed study of the halex Cl - /F - exchange reaction of activated aryl chlorides, for example the conversion of 1,2-dichloro-4-nitrobenzene to 2-chloro-1-fluoro-4-nitrobenzene in DMSO at 120oC showed tetramethylammonium chloride to be superior to other common phase-transfer catalysts. It was necessary to pre-dry the catalyst to <0.2% water to avoid competition from hydrolytic displacement: Chem. Commun., 297 (1996).

Compare also Tetraphenyl­phosphonium bromide, A15860 and Tetraphenyl­phosphonium chloride, A10575.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H311-H315-H319-H335

Toxic if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P280h-P305+P351+P338-P309-P310

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Other References

Beilstein
2496575
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2923.90
TSCA
Yes
RTECS
BS7700000

Recommended

  • A13368

    Tetramethylammonium bromide, 98%
  • A15828

    Choline chloride, 98+%
  • L13278

    Sodium cyanide, granules, 98%
  • 13641

    Cerium(III) iodide, ultra dry, 99.9% (REO)
  • A10249

    Tetra-n-butylammonium bromide, 98+%

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware