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7143-01-3 - Methanesulfonic anhydride, 98% - Mesic anhydride - A13328 - Alfa Aesar

A13328 Methanesulfonic anhydride, 98%

CAS Number
7143-01-3
Synonyms
Mesic anhydride

Size Price ($) Quantity Availability
10g 26.06
25g 62.62
50g 105.50
250g 517.06
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Methanesulfonic anhydride, 98%

MDL
MFCD00007556
EINECS
230-442-1

Chemical Properties

Formula
C2H6O5S2
Formula Weight
174.20
Melting point
65-69°
Boiling Point
125°/4mm
Sensitivity
Moisture Sensitive
Solubility
Soluble in organic solvents.

Applications

Methanesulfonic anhydride is used to prepare methylsulfonyl esters called as mesylates. It finds application in the reaction of aromatic alkylation. It reacts with dimethylsulfoxide to get sulfoxonium complex, which is a useful oxidizing agent.

Notes

Moisture sensitive. Hygroscopic. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Literature References

More powerful sulfonylating reagent than the sulfonyl chloride, also avoiding possible displacement of sulfonate by halide. With a catalytic amount of the acid effects mesylation of deactivated aromatics such as 1,3-dichlorobenzene: Chem. Lett., 395 (1988); mesyl chloride is ineffective.

Primary and secondary alcohols may be oxidized to carbonyl compounds by sulfonic anhydrides in DMSO: J. Org. Chem., 39, 1977 (1974). For related methods, see Dimethyl­ sulfoxide, A13280.

Liu, W., Tilley, T. D. Sterically Controlled Functionalization of Carbon Surfaces with- C6H4CH2X (X= OSO2Me or N3) Groups for Surface Attachment of Redox-Active Molecules. Langmuir 2015, 31 (3), 1189-1195.

Hu, Y.; Zhang, F.; Zhang, C.; Zhang, M. Anti-inflammatory Properties of an Active Sesquiterpene Lactone and its Structure-Activity Rela-tionship. Med chem 2015, 5, 354-360.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
972316
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2904.10
TSCA
Yes

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