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A13377 4-Fluorobenzotrifluoride, 98+%

CAS Number
402-44-8
Synonyms
alpha,alpha,alpha,4-Tetrafluorotoluene

Stock No. Size Price ($) Quantity Availability
A13377-06 5g 38.60
A13377-14 25g 146.00
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4-Fluorobenzotrifluoride, 98+%

MDL
MFCD00000399
EINECS
206-944-1

Chemical Properties

Formula
C7H4F4
Formula Weight
164.10
Melting point
-42°
Boiling Point
103-105°
Flash Point
10°(50°F)
Density
1.295
Refractive Index
1.4010
Storage & Sensitivity
Ambient temperatures.
Solubility
Slightly soluble in water.

Applications

4-Fluorobenzotrifluoride was used in the synthesis of 2,2?-bis(trifluoromethylphenoxy)biphenyl via nucleophilic aromatic substitution reaction with 2,2?-biphenol, (S)-fluoxetine, potent inhibitor of neuronal serotonin-uptake and 1-aryloxy-2-substituted aminomethyltetrahydronaphthalene derivatives.

Notes

Store in cool, dry place in tightly closed container. Store away from oxidizing agent.

Literature References

Akiko Okamoto; Katsuya Maeyama; Keiichi Noguchi; Hideaki Oike; Yoshihiko Murakami; Noriyuki Yonezawa. Synthesis of novel trifluoromethyl-bearing bifunctional acyl-acceptant arenes: 2,2'-bis(trifluoromethylated aryloxy)biphenyls. Journal of Oleo Science,. 2007, 56 (9),479-491.

D W Robertson et. al. Absolute configurations and pharmacological activities of the optical isomers of fluoxetine, a selective serotonin-uptake inhibitor. Journal of Medicinal Chemistry, 1988, 31 (7), 1412-1417.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1909390
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2903.99
TSCA
Yes

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