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Phenethylamine is used in manufacturing anti-depression agents and anti diabetic drugs. It is also used as the goodds for drug jiangtangling intermediate, also used for other organic synthesis.
HC Sabelli.; AD Mosnaim. Phenylethylamine hypothesis of affective behavior. American Journal of Psychiatry. 1974, 131,(6), 695-699.
DA Durden.; SR Philips. Identification and distribution of β-phenylethylamine in the rat. Canadian Journal of Biochemistry. 1973, 51,(7), 995-1002.
N-Acyl-derivatives are cyclized by a variety of reagents, e.g. P2O5, POCl3, PCl5, etc., to derivatives of isoquinoline, in the Bischler-Napieralski synthesis. For a review, see: Org. React., 6, 74 (1951). Similarly, imines can be cyclized to derivatives of tetrahydroisoquinoline in the Pictet-Spengler synthesis. Reviews: Org. React., 6, 151 (1951); Adv. Het. Chem., 3, 79 (1964); Heterocycles, 3, 223 (1975); 39, 903 (1994).
Hazard Statements: H227-H301-H314-H318
Combustible liquid. Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P210u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
IF SWALLOWED: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.