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2632-13-5 - 2-Bromo-4'-methoxyacetophenone, 98% - 4-Methoxyphenacyl bromide - alpha-Bromo-4-methoxyacetophenone - A13415 - Alfa Aesar

A13415 2-Bromo-4'-methoxyacetophenone, 98%

CAS Number
2632-13-5
Synonyms
4-Methoxyphenacyl bromide
alpha-Bromo-4-methoxyacetophenone

Size Price ($) Quantity Availability
5g 28.43
25g 104.03
100g 290.46
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2-Bromo-4'-methoxyacetophenone, 98%

MDL
MFCD00000201
EINECS
220-118-8

Chemical Properties

Formula
C9H9BrO2
Formula Weight
229.08
Melting point
68-72°
Solubility
It is soluble in DMSO, water (partly miscible), most organic solvents, and methanol.

Applications

2-Bromo-4'-methoxyacetophenone, is used as a cell-permeable, covalent and potent protein tyrosine phosphatase inhibitor.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C

Literature References

W Zhang.; DP Curran.; CHT Chen. Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis. Tetrahedron letters. 2002, 58,(20), 3871-3875.

Y Nishiyama.; A Kobayashi. Synthesis of 1, 4-diketones: reaction of α-bromo ketones with tetrakis (dimethylamino) ethylene (TDAE). Tetrahedron letters. 2006, 47,(31), 5565-5567.

Reagent for protection of carboxylic acids as 4-methoxyphenacyl esters, which may be prepared in the presence of KF as base: Synthesis, 897 (1981) and can be cleaved photolytically: J. Org. Chem., 38, 3771 (1973). Peptide bonds are generally unaffected by irradiation but some cleavage of trityl protecting groups may occur. See also Appendix 6. For further discussion of this and other photo-removable protecting groups, see: Synthesis, 1 (1980); Org. Photochem., 9, 225 (1987).

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P280-P305+P351+P338-P309-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Other References

Beilstein
743112
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2914.70
TSCA
No

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