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A13442 Isonipecotamide, 98%

CAS Number
39546-32-2
Synonyms
Hexahydroisonicotinamide
Piperidine-4-carboxamide

Stock No. Size Price ($) Quantity Availability
A13442-09 10g 17.70
A13442-18 50g 51.50
A13442-30 250g 197.00
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Isonipecotamide, 98%

MDL
MFCD00038012
EINECS
254-501-6

Chemical Properties

Formula
C6H12N2O
Formula Weight
128.18
Melting point
148-149°
Storage & Sensitivity
Hygroscopic. Store under Nitrogen. Ambient temperatures.
Solubility
Soluble in water.

Applications

Isonipecotamide is used as a reactant for the preparation of Survival motor neuron (SMN) protein modulators, orally available naphthyridine protein kinase D inhibitors and heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase. It is also used to prepare phosphodiesterase 5 inhibitors. It is also used as a reactant for identification of small molecular inhibitors of importin-beta mediated nuclear import. It is also used as a fluorenylmethyloxycarbonyl - deprotection agent in organic synthesis.

Notes

Moisture sensitive. Hygroscopic. Incompatible with strong oxidizing agents.

Literature References

de Candia, M.; Marini, E.; Zaetta, G.; Cellamare, S.; Di Stilo, A.; Altomare, C. D. New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity. Eur. J. Pharm. Sci. 2015, 72, 69-80.

Chandrashekhara, K. G.; Gopalakrishna, B. N.; Nagaraj, P. Spectrophotometric determination of chromium by using sulphanilic acid and N, N-dimethylaniline. Indian J. Chem. Technol. 2015, 22 (1-2), 78-81.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
112554
Harmonized Tariff Code
2933.39
TSCA
Yes

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