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39546-32-2 - Isonipecotamide, 98% - Hexahydroisonicotinamide - Piperidine-4-carboxamide - A13442 - Alfa Aesar

A13442 Isonipecotamide, 98%

CAS Number
39546-32-2
Synonyms
Hexahydroisonicotinamide
Piperidine-4-carboxamide

Size Price ($) Quantity Availability
10g 15.86
50g 51.00
250g 205.00
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Isonipecotamide, 98%

MDL
MFCD00038012
EINECS
254-501-6

Chemical Properties

Formula
C6H12N2O
Formula Weight
128.18
Melting point
148-149°
Sensitivity
Hygroscopic
Solubility
Soluble in water.

Applications

Isonipecotamide is used as a reactant for the preparation of Survival motor neuron (SMN) protein modulators, orally available naphthyridine protein kinase D inhibitors and heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase. It is also used to prepare phosphodiesterase 5 inhibitors. It is also used as a reactant for identification of small molecular inhibitors of importin-beta mediated nuclear import. It is also used as a fluorenylmethyloxycarbonyl - deprotection agent in organic synthesis.

Notes

Moisture sensitive. Hygroscopic. Incompatible with strong oxidizing agents.

Literature References

de Candia, M.; Marini, E.; Zaetta, G.; Cellamare, S.; Di Stilo, A.; Altomare, C. D. New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity. Eur. J. Pharm. Sci. 2015, 72, 69-80.

Chandrashekhara, K. G.; Gopalakrishna, B. N.; Nagaraj, P. Spectrophotometric determination of chromium by using sulphanilic acid and N, N-dimethylaniline. Indian J. Chem. Technol. 2015, 22 (1-2), 78-81.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
112554
Harmonized Tariff Code
2933.39
TSCA
Yes

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