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1660-95-3 - Tetraisopropyl methylenediphosphonate, 98% - Methylenediphosphonic acid tetraisopropyl ester - Methylenephosphonic acid tetraisopropyl ester - A13484 - Alfa Aesar

A13484 Tetraisopropyl methylenediphosphonate, 98%

CAS Number
1660-95-3
Synonyms
Methylenediphosphonic acid tetraisopropyl ester
Methylenephosphonic acid tetraisopropyl ester

Size Price ($) Quantity Availability
10g 42.54
50g 149.35
250g 512.80
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Tetraisopropyl methylenediphosphonate, 98%

MDL
MFCD00015021
EINECS
216-765-0

Chemical Properties

Formula
C13H30O6P2
Formula Weight
344.33
Boiling Point
122-124°/1.5mm
Flash Point
160°(320°F)
Density
1.080
Refractive Index
1.4340
Solubility
Insoluble in water.

Applications

Tetraisopropyl methylenediphosphonate is used in the preparation of AZT 5’-Triphosphate compounds which display inhibitory effects on HIV-1 reverse transcrpitase. It is also used in the preparation of E2-bisphosphonate conjugates.

Notes

Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Literature References

Richard D. Chambers.; John Hutchinson. Elemental fluorine. Part 91: Catalysis of the direct fluorination of 2-substituted carbonyl compounds2. Journal of Fluorine Chemistry. 1998, 92, (1), 45-52.

Andrzej W. Trochimczuk. Novel ion-exchange/coordination resin with carboxyethyl phosphonate ligands. European Polymer Journal. 1998, 34, (7), 1047-1051.

Horner-Wadsworth-Emmons olefination (see Appendix 1) with carbonyl compounds yields vinylphosphonates: Synth. Commun., 10, 299 (1980). A synthesis of allenes via a double HWE olefination has been described: Tetrahedron, 58, 83 (2002):

gem-Bisphosphonates have application in bone tissue therapy: Synthesis, 661 (1991).

GHS Hazard and Precautionary Statements

Hazard Statements: H318

Causes serious eye damage.

Precautionary Statements: P280-P305+P351+P338-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.

Other References

Beilstein
1080180
Harmonized Tariff Code
2931.90
TSCA
Yes

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