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Tetraisopropyl methylenediphosphonate is used in the preparation of AZT 5-Triphosphate compounds which display inhibitory effects on HIV-1 reverse transcrpitase. It is also used in the preparation of E2-bisphosphonate conjugates.
Richard D. Chambers.; John Hutchinson. Elemental fluorine. Part 91: Catalysis of the direct fluorination of 2-substituted carbonyl compounds2. Journal of Fluorine Chemistry. 1998, 92, (1), 45-52.
Andrzej W. Trochimczuk. Novel ion-exchange/coordination resin with carboxyethyl phosphonate ligands. European Polymer Journal. 1998, 34, (7), 1047-1051.
Horner-Wadsworth-Emmons olefination (see Appendix 1) with carbonyl compounds yields vinylphosphonates: Synth. Commun., 10, 299 (1980). A synthesis of allenes via a double HWE olefination has been described: Tetrahedron, 58, 83 (2002):
gem-Bisphosphonates have application in bone tissue therapy: Synthesis, 661 (1991).
Hazard Statements: H318
Causes serious eye damage.
Precautionary Statements: P280i-P305+P351+P338-P310a
Wear eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor