I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Tetraisopropyl methylenediphosphonate is used in the preparation of AZT 5-Triphosphate compounds which display inhibitory effects on HIV-1 reverse transcrpitase. It is also used in the preparation of E2-bisphosphonate conjugates.
Richard D. Chambers.; John Hutchinson. Elemental fluorine. Part 91: Catalysis of the direct fluorination of 2-substituted carbonyl compounds2. Journal of Fluorine Chemistry. 1998, 92, (1), 45-52.
Andrzej W. Trochimczuk. Novel ion-exchange/coordination resin with carboxyethyl phosphonate ligands. European Polymer Journal. 1998, 34, (7), 1047-1051.
Horner-Wadsworth-Emmons olefination (see Appendix 1) with carbonyl compounds yields vinylphosphonates: Synth. Commun., 10, 299 (1980). A synthesis of allenes via a double HWE olefination has been described: Tetrahedron, 58, 83 (2002):
gem-Bisphosphonates have application in bone tissue therapy: Synthesis, 661 (1991).
Hazard Statements: H318
Causes serious eye damage.
Precautionary Statements: P260-P201-P280i-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.