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A13489 1-Chloro-3-iodopropane, 98%, stab. with copper

CAS Number
6940-76-7
Synonyms
Trimethylene chloroiodide

Stock No. Size Price ($) Quantity Availability
A13489-14 25g 45.40
A13489-22 100g 126.00
A13489-36 500g 488.00
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1-Chloro-3-iodopropane, 98%, stab. with copper

MDL
MFCD00001096
EINECS
230-088-8

Chemical Properties

Formula
ClCH2CH2CH2I
Formula Weight
204.44
Boiling Point
170-172°
Flash Point
>110°(230°F)
Density
1.904
Refractive Index
1.5463
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubility
Difficult to mix.

Applications

1-Chloro-3-iodopropane has been used in the synthesis of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid, an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase), interesting proton sponge type molecule quino[7,8-h]quinoline.

Notes

Light Sensitive. Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Jen-Yen Cheng.; Yen-Ho Chu. 1-Butyl-2,3-trimethyleneimidazolium bis(trifluoromethylsulfonyl)imide ([b-3C-im][NTf2]): a new, stable ionic liquid. Tetrahedron Letters. 2006, 47, (10), 1575-1579.

T. B. Scoggins.; J. M. White. The Thermal Chemistry of 1-Chloro-3-Iodopropane (ClC3H6I) Adsorbed on Pt(111). J. Phys. Chem. B. 1999, 103, (44), 9663-9672.

Bifunctional alkylating agent in which the two halogens may be displaced successively with different nucleophiles. For use in the alkylation of diphenyl sulfide and cyclization to the cyclopropyl diphenyl sulfonium salt, see: Org. Synth. Coll., 6, 364 (1988).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1731115
Harmonized Tariff Code
2903.79
TSCA
Yes

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