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Succinimide is used in organic syntheses and in industrial silver plating processes. It is also used as anticonvulsant drugs such as ethosuximide, phensuximide and methsuximide. Further, it is used to form covalent bonds between proteins, peptides and plastics. In addition to this, it is used as an important raw material for the synthesis of heterocyclic compounds through N-acyliminium cyclizations.
With the cycloalkenylation agent (1-Ethoxycarbonylcyclopropyl)triphenylphosphonium tetrafluoroborate, A18305, gives a bridgehead lactam (pyrrolizinone) which is an intermediate in a diastereoselective synthesis of (±)-isoretronecanol: Liebigs Ann. Chem., 521 (1983):
Peng, H.; Kather, M.; Ru?bsam, K.; Jakob, F.; Schwaneberg, U.; Pich, A. Water-Soluble Reactive Copolymers Based on Cyclic N-Vinylamides with Succinimide Side Groups for Bioconjugation with Proteins. Macromolecules 2015, 48 (13), 4256-4268.
Habibi, A.; Soltanloo, Z.; Beiraghi, A.; Valizadeh, Y. One-pot synthesis of new dye derivatives of succinimide via three-component reaction of alkylidene Meldrum's acid, isocyanides and p-aminoazobenzene derivatives. Dyes Pigm. 2015, 113, 481-486.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant