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Chromone-2-carboxylic acid is used in the cyclic form 3?-oxopyrazolidino[4?,5??2, 3]-chroman-4-one, gives the azide of chromone-2-carboxylic acid, the curtius rearrangement of which is used to synthesize a number of 2-acylaminochromones and it is an orally active antiallergic agent.
W.J.S. Lockley. Regioselective deuteration of aromatic and α,β-unsaturated carboxylic acids via rhodium(III) chloride catalyzed exchange with deuterium oxide. Tetrahedron Letters. 1982, 23, (37), 3819-3822.
Keishi Ohara.; Kazuo Mukai. Anomalous spin polarization in the photoreduction of chromone-2-carboxylic acid with alcohol induced by hydrochloric acid. Chemical Physics Letters. 2000, 317, (6), 619-623.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.