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1,1,1-Trifluoroacetone is used in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction. And also used as a useful molecule in synthesis reactions.
Gandini, A.; Hackett, P.A. Electronic relaxation processes in acetone and 1,1,1-trifluoroacetone vapor and the gas phase recombination of the acetyl radical at 22.degree.C. J. Am. Chem. Soc. 1977, 99, (19), 6195-6205.
Jonathan O. Smith.; Braja K. Mandal.; Robert Filler.; James W. Beery. Reaction of ethyl 4,4,4-trifluoroacetoacetate enolate with 3-bromo-1,1,1-trifluoroacetone: synthesis of 2,4-bis (trifluoromethyl) furan. Journal of Fluorine Chemistry. 1977, 81, (2), 123-128.
Hazard Statements: H224-H315-H319-H335
Extremely flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.