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A13556 1,1,1-Trifluoroacetone, 95%

CAS Number
421-50-1
Synonyms
1,1,1-Trifluoro-2-propanone

Stock No. Size Price ($) Quantity Availability
A13556-14 25g 98.50
A13556-22 100g 255.00
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1,1,1-Trifluoroacetone, 95%

MDL
MFCD00000423
EINECS
207-005-9

Chemical Properties

Formula
CF3COCH3
Formula Weight
112.05
Melting point
<-78°
Boiling Point
21-24°
Flash Point
-31°(-24°F)
Density
1.252
Refractive Index
1.3000
Storage & Sensitivity
Keep Cold. Hygroscopic. Store under Nitrogen.
Solubility
Insoluble in water.

Applications

1,1,1-Trifluoroacetone is used in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction. And also used as a useful molecule in synthesis reactions.

Notes

Air Sensitive. Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Literature References

Gandini, A.; Hackett, P.A. Electronic relaxation processes in acetone and 1,1,1-trifluoroacetone vapor and the gas phase recombination of the acetyl radical at 22.degree.C. J. Am. Chem. Soc. 1977, 99, (19), 6195-6205.

Jonathan O. Smith.; Braja K. Mandal.; Robert Filler.; James W. Beery. Reaction of ethyl 4,4,4-trifluoroacetoacetate enolate with 3-bromo-1,1,1-trifluoroacetone: synthesis of 2,4-bis (trifluoromethyl) furan. Journal of Fluorine Chemistry. 1977, 81, (2), 123-128.

GHS Hazard and Precautionary Statements

Hazard Statements: H224-H314-H335

Extremely flammable liquid and vapour. Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1748614
Hazard Class
3
Packing Group
I
Harmonized Tariff Code
2914.79
TSCA
Yes

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