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4-(4-Nitrobenzyl)pyridine is used in spectroscopic method for the determination of phosgene. It is also used in tests for alkylating agents.
Reagent for the determination of phosgene: Analyst, 84, 463 (1959); and other acylating or alkylating species: Talanta, 13 , 1151 (1966); Cancer Research, 30, 1651 (1970); 31, 901 (1971).
Xue, F.; Liu, Z.; Wan, N.; Zhu, H.; Zheng, Y. Engineering the epoxide hydrolase from Agromyces mediolanus for enhanced enantioselectivity and activity in the kinetic resolution of racemic epichlorohydrin. RCS Adv. 2015, 5 (40), 31525-31532.
Vanek, V.; Picha, J.; Fabre, B.; Budesinsky, M.; Lepsik, M.; Jiracek, J. The Development of a Versatile Trifunctional Scaffold for Biological Applications. Eur. J. Org. Chem. 2015, 2015 (17), 3689-3701.
Hazard Statements: H302-H315-H319-H335-H340
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause genetic defects.
Precautionary Statements: P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P337+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear eye/face protection. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant