Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

A13565 Methanesulfonic acid, 98+%

CAS Number
75-75-2
Synonyms
Mesic acid
Methylsulfonic acid

Stock No. Size Price ($) Quantity Availability
A13565-22 100g 25.80
A13565-36 500g 46.80
A13565-0E 2500g 192.00
Add to Cart Bulk/Specialty Print Quote View Item

Methanesulfonic acid, 98+%

MDL
MFCD00007518
EINECS
200-898-6

Chemical Properties

Formula
CH4O3S
Formula Weight
96.10
Melting point
19-20°
Boiling Point
166-168°/10mm
Flash Point
156°(312°F)
Density
1.481
Refractive Index
1.4300
Storage & Sensitivity
Hygroscopic. Store under Nitrogen. Ambient temperatures.
Solubility
Miscible with water. Slightly miscible with benzene and toluene. Immiscible with paraffins.

Applications

Methanesulfonic acid is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents. It is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters. It reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex. It finds application in batteries, because of its purity and chloride absence. In pharmaceutical industry, it is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan. It is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.It is involved in the deprotection of peptides.

Notes

Moisture, light and heat sensitive. Hygroscopic. Keep container tightly closed in a dry and well-ventilated place. Incompatible with amines, strong reducing agents, ethyl vinyl ether, hydrofluoric acid, strong oxidizing agents and bases.

Literature References

Strong acid which has been used for the deprotection of peptides; see Appendix 6.

Cleaves methyl ethers of phenols in the presence of the soft nucleophile methionine as a methyl acceptor. Polymethoxyaldehydes or ketones undergo selective cleavage of the methoxy group meta to the carbonyl: J. Chem. Soc., Perkin 1, 2288 (1977). Similarly, in combination with dimethyl sulfide, selective O-demethylation of mixed phosphate esters occurs: Synthesis, 451 (1983).

Sandoval, A. P.; Herrera, M. F. S.; Climent, V.; Feliu, J. M. Interaction of water with methanesulfonic acid on Pt single crystal electrodes. Electrochem. Commun. 2015, 50, 47-50.

Chen, H.; Ezell, M. J.; Arquero, K. D.; Varner, M. E.; Dawson, M. L.; Gerber, R. B.; Pitts, B. J. F. New particle formation and growth from methanesulfonic acid, trimethylamine and water. Phys. Chem. Chem. Phys. 2015, 17 (20), 13699-13709.

GHS Hazard and Precautionary Statements

Hazard Statements: H290-H302-H312-H314-H335

May be corrosive to metals. Harmful if swallowed. Harmful in contact with skin. Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P234-P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P390-P501c

Keep only in original container. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Absorb spillage to prevent material damage. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,5954
Beilstein
1446024
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2904.10
TSCA
Yes
RTECS
PB1140000

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware