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75-75-2 - Methanesulfonic acid, 98+% - Mesic acid - Methylsulfonic acid - A13565 - Alfa Aesar

A13565 Methanesulfonic acid, 98+%

CAS Number
75-75-2
Synonyms
Mesic acid
Methylsulfonic acid

Size Price ($) Quantity Availability
100g 23.59
500g 44.91
2500g 183.34
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Methanesulfonic acid, 98+%

MDL
MFCD00007518
EINECS
200-898-6

Chemical Properties

Formula
CH4O3S
Formula Weight
96.10
Melting point
19-20°
Boiling Point
166-168°/10mm
Flash Point
156°(312°F)
Density
1.481
Refractive Index
1.4300
Sensitivity
Light Sensitive & Hygroscopic
Solubility
Miscible with water. Slightly miscible with benzene and toluene. Immiscible with paraffins.

Applications

Methanesulfonic acid is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents. It is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters. It reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex. It finds application in batteries, because of its purity and chloride absence. In pharmaceutical industry, it is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan. It is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.It is involved in the deprotection of peptides.

Notes

Moisture, light and heat sensitive. Hygroscopic. Keep container tightly closed in a dry and well-ventilated place. Incompatible with amines, strong reducing agents, ethyl vinyl ether, hydrofluoric acid, strong oxidizing agents and bases.

Literature References

Strong acid which has been used for the deprotection of peptides; see Appendix 6.

Cleaves methyl ethers of phenols in the presence of the soft nucleophile methionine as a methyl acceptor. Polymethoxyaldehydes or ketones undergo selective cleavage of the methoxy group meta to the carbonyl: J. Chem. Soc., Perkin 1, 2288 (1977). Similarly, in combination with dimethyl sulfide, selective O-demethylation of mixed phosphate esters occurs: Synthesis, 451 (1983).

Sandoval, A. P.; Herrera, M. F. S.; Climent, V.; Feliu, J. M. Interaction of water with methanesulfonic acid on Pt single crystal electrodes. Electrochem. Commun. 2015, 50, 47-50.

Chen, H.; Ezell, M. J.; Arquero, K. D.; Varner, M. E.; Dawson, M. L.; Gerber, R. B.; Pitts, B. J. F. New particle formation and growth from methanesulfonic acid, trimethylamine and water. Phys. Chem. Chem. Phys. 2015, 17 (20), 13699-13709.

GHS Hazard and Precautionary Statements

Hazard Statements: H314

Causes severe skin burns and eye damage.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,5954
Beilstein
1446024
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2904.10
TSCA
Yes
RTECS
PB1140000

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