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2-Iodophenol is used in the synthesis of aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity and 3,3-disubstituted-2,3-dihydrobenzofurans. Coupling with phenylacetylene in the presence of a Pd complex and CuI gives 2-phenylbenzofuran in good yield.
Kazumi Okuro.; Howard Alper. Palladium-Catalyzed Carbonylation of o-Iodophenols with Allenes. J. Org. Chem. 1997, 62 (6), 1566-1567.
Maurizio Botta.; Vincenzo Summa.; Federico Corelli.; Giovanna Di Pietro.; Paolo Lombardi. Synthesis of aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity via palladium-catalyzed heteroannulation of chiral arylpropargylic alcohols. Tetrahedron: Asymmetry. 1996, 7 (5), 1263-1266.
Coupling with phenylacetylene in the presence of a Pd complex and CuI gives 2-phenylbenzofuran in good yield: Synlett, 515 (1992); J. Chem. Soc., Perkin 1, 2815 (1997):
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
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