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Diethylamine hydrochloride acts as a precursor of atrazine and lysergic acid diethylamide. It is also used as a reactant in the production of dyes and pharmaceutical compounds such as ranitidine. Further, it is used in Mannich reaction with paraformaldehyde. In addition to this, it is employed in the synthesis of diethylaminoethyl (DEAE) cottons by reacting with cotton cellulose in the presence of sodium hydroxide.
For Mannich reaction with paraformaldehyde and acetone, see: Org. Synth. Coll., 4, 281 (1963).
Xiao, J.; Huang, Y.; Song, Z.; Feng, W. Facile catalyst-free synthesis of 2-vinylquinolines via a direct deamination reaction occurring during Mannich synthesis. RSC Adv. 2015, 5 (120), 99095-99098.
Zavozin, A. G.; Ignat'ev, N. V.; Schulte, M.; Zlotin, S. G. Synthesis of novel tridentate pyrazole-bipyridine ligands for Co-complexes as redox-couples in dye-sensitized solar cells. Tetrahedron 2015, 71 (45), 8551-8556.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.