I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Diethyl bis(hydroxymethyl)malonate is used as a reagent for preparing 1,3-dioxanes from acetals, aldehydes and ketones. It is also used as an intermediate for the preparation of substituted malonic, acrylic and isobutyric esters, for conversion to the useful dienophiles, ?-bromomethylacrylic acid and its ethyl ester and to bis(bromomethyl)acetic acid and its methyl ester.
Ross A. Miller.; Fengrui Lang.; Benjamin Marcune.; Daniel Zewge.; Zhiguo J. Song.; Sandor Karady. A Practical Process for the Preparation of Azetidine-3-carboxylic Acid. Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry. 2003, 33 (19), 3347-3353.
Shiyue Fang.; Donald E. Bergstrom. Reversible Biotinylation Phosphoramidite for 5-End-Labeling, Phosphorylation, and Affinity Purification of Synthetic Oligonucleotides. Bioconjugate Chem. 2003, 14 (1), 80-85.
Intermediate for the preparation of substituted malonic, acrylic and isobutyric esters: J. Chem. Soc., 257 (1930); J. Org. Chem., 20, 780 (1955). For conversion to the useful dienophiles, ɑ-bromomethylacrylic acid and its ethyl ester, see: Org. Synth. Coll., 7, 210 (1990), and to bis(bromomethyl)acetic acid and its methyl ester, Org. Synth. Coll., 7, 319 (1990).