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Chlorotriphenylsilane is used as a silylating agent. It is also used as a pharmaceutical intermediate.
Raymond C. Petersen.; Sidney D. Ross. Displacement Reactions on Silicon. The Reaction of 2-Propanol with Chlorotriphenylsilane in Carbon Tetrachloride. J. Am. Chem. Soc. 1963, 85 (20), 3164-3167.
Henry Gilman.; Glen D. Lichtenwalter. Cleavage of Symmetrically Substituted Disilanes by Lithium in Tetrahydrofuran. J. Am. Chem. Soc. 1958, 80 (3), 608-611.
Silylating agent: J. Chem. Soc., 3403 (1963); see Appendix 4. The stability of the bulky triphenylsilyl (TPS) ethers to basic hydrolysis is similar to TMS, but they are about 400x more stable to acid hydrolysis. Suitable conditions for their cleavage include: ethanolic NaOH; AcOH - water - THF at 70o: Chem. Lett., 1499 (1979); and TBAF: J. Am .Chem. Soc., 108, 3827 (1986).
Hazard Statements: H314
Causes severe skin burns and eye damage.
Precautionary Statements: P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant