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Diethyl aminomalonate hydrochloride is used as a pharmaceutical intermediate. Diethyl aminomalonate with formaldehyde generates an azomethine ylide which can undergo cycloadditions with 1,2-dipolarophiles to form pyrrolidines.
Mario D. Bachi.; Nira Bar-Ner.; Charles M. Crittell.; Peter J. Stang.; Bobby L. Williamson. Synthesis of alkynyl(phenyl)iodonium triflates and their reaction with diethyl 2-aminomalonate. J. Org. Chem. 1991, 56 (12), 3912-3915.
Ning Chen.; Yuelie Lu.; Kumar Gadamasetti.; Clarence R. Hurt.; Mark H. Norman.; Christopher Fotsch. A Short, Facile Synthesis of 5-Substituted 3-Amino-1H-pyrrole-2-carboxylates. J. Org. Chem. 2000, 65 (8), 2603-2605.
Diethyl aminomalonate with formaldehyde generates an azomethine ylide which can undergo cycloadditions with 1,2-dipolarophiles to form pyrrolidines: Tetrahedron Lett., 29, 6649 (1988):
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.