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A13690 1-Chloro-4-fluorobenzene, 98%

CAS Number
352-33-0
Synonyms
4-Chlorofluorobenzene

Stock No. Size Price ($) Quantity Availability
A13690-14 25g 44.90
A13690-22 100g 169.00
A13690-36 500g 665.00
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1-Chloro-4-fluorobenzene, 98%

MDL
MFCD00000603
EINECS
206-521-1

Chemical Properties

Formula
C6H4ClF
Formula Weight
130.55
Melting point
-22°
Boiling Point
129-130°
Flash Point
29°(84°F)
Density
1.228
Refractive Index
1.4950
Storage & Sensitivity
Ambient temperatures.
Solubility
Difficult to mix.

Applications

1-Chloro-4-fluorobenzeneis used as a primary and secondary intermediates, organic synthesis. And it is also used to prepare (4'-fluoro-biphenyl-4-yl)-methyl ether by using reagents NaH, Ni (OAc)2, 2,2 '-bipyridyl, KI and solvents benzene, tetrahydrofuran at temperature of 63°C.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Lithiation with LDA occurs mainly ortho to F; subsequent carboxylation gives 5-chloro-2-fluorobenzoic acid in moderate yield: Tetrahedron Lett., 33, 7495 (1992). The selectivity is improved by the use of the superbasic combination of n-BuLi and KO-t-Bu, and the yield is increased to 86%: Tetrahedron Lett., 37, 6551 (1996).

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P261-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1904542
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2903.99
TSCA
Yes

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