A13692 1,3-Dimethylbarbituric acid, 99% (dry wt.), water <6%
SDS
1,3-Dimethylbarbituric acid, 99% (dry wt.), water <6%
Chemical Properties
Applications
1,3-Dimethylbarbituric acid is used as a catalyst in the Knoevenagel condensation of a series of aromatic aldehydes. It is also used in the synthesis of 5-aryl-6-(alkyl- or aryl-amino)-1,3-dimethylfuro [2,3-d]pyrimidine derivatives and enantioselective synthesis of isochromene pyrimidinedione derivatives.
Notes
Literature References
Shih, Y. C.; Tsai, P. H.; Hsu, C. C.; Chang, C. W.; Jhong, Y.; Chen, Y. C.; Chien, T. C. Biomimetic Approach toward the Total Synthesis of rac-2-(Acylmethylene)pyrrolidine Alkaloids. J. Org. Chem. 2015, 80 (13), 6669-6678.
Myochin, T.; Hanaoka, K.; Iwaki, S.; Ueno, T.; Komatsu, T.; Terai, T.; Nagano, T.; Yasuteru Urano,Y. Development of a Series of Near-Infrared Dark Quenchers Based on Si-rhodamines and Their Application to Fluorescent Probes. J. Am. Chem. Soc. 2015, 137 (14), 4759-4765.
GHS Hazard and Precautionary Statements
Hazard Statements: H302-H318
Harmful if swallowed. Causes serious eye damage.
Precautionary Statements: P280i-P264-P305+P351+P338-P310a-P301+P312a-P501a
Wear eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Dispose of contents/container in accordance with local/regional/national/international regulations.
