I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Methyl acetoacetate is used as a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.Methyl acetoacetate (MAA) is used for the synthesis of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.
Michael M. Folkendt; Boris E. Weiss-Lopez; J. Paul ChauvelJr; Nancy S. True. Gas-phase proton NMR studies of keto-enol tautomerism of acetylacetone, methyl acetoacetate, and ethyl acetoacetate.J. Phys. Chem.1985, 89 (15), 3347-3352.
Mark A. Keane; Geoffrey Webb. The enantioselective hydrogenation of methyl acetoacetate over supported nickel catalysts: I. The modification procedure.Journal of Catalysis.1992, 136 1-15.
Hazard Statements: H227-H319
Combustible liquid. Causes serious eye irritation.
Precautionary Statements: P210u-P280a-P305+P351+P338-P337+P313-P403+P235-P501a
Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.