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Methyl acetoacetate is used as a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.Methyl acetoacetate (MAA) is used for the synthesis of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.
Michael M. Folkendt; Boris E. Weiss-Lopez; J. Paul ChauvelJr; Nancy S. True. Gas-phase proton NMR studies of keto-enol tautomerism of acetylacetone, methyl acetoacetate, and ethyl acetoacetate.J. Phys. Chem.1985, 89 (15), 3347-3352.
Mark A. Keane; Geoffrey Webb. The enantioselective hydrogenation of methyl acetoacetate over supported nickel catalysts: I. The modification procedure.Journal of Catalysis.1992, 136 1-15.
Hazard Statements: H227-H319
Combustible liquid. Causes serious eye irritation.
Precautionary Statements: P210-P264b-P280-P305+P351+P338-P337+P313-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant